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Pathway : TGF-beta signaling pathway

Identifier  04350 Description  The transforming growth factor-beta TGF-beta family members, which include TGF-betas, activins and bone morphogenetic proteins BMPs, are structurally related secreted cytokines found in species ranging from worms and insects to mammals A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I The Type I receptor, in turn, phosphorylates receptor-activated Smads R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8 Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator or co-repressor proteins

1 Data Sets

169 Genes

0 Proteins