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Pathway : Thyroid cancer

Identifier  05216 Description  Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year More than 95% of thyroid carcinomas are derived from follicular cells  Their behavior varies from the indolent growing, well-differentiated papillary and follicular carcinomas PTC and FTC, respectively to the extremely aggressive undifferentiated carcinoma UC Somatic rearrangements of RET and TRK are almost exclusively found in PTC and may be found in early stages The most distinctive molecular features of FTC are the prominence of aneuploidy and the high prevalence of RAS mutations and PAX8-PPAR{gamma} rearrangements p53 seems to play a crucial role in the dedifferentiation process of thyroid carcinoma

1 Data Sets

59 Genes

0 Proteins