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Pathway : Dilated cardiomyopathy

Identifier  05414 Description  Dilated cardiomyopathy DCM is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac death from ventricular arrhythmia Genetically inherited forms of DCM "familial" DCM have been identified in 25-35% of patients presenting with this disease, and the inherited gene defects are an important cause of "familial" DCM The pathophysiology may be separated into two categories: defects in force generation and defects in force transmission In cases where an underlying pathology cannot be identified, the patient is diagnosed with an "idiopathic" DCM Current hypotheses regarding causes of "idiopathic" DCM focus on myocarditis induced by enterovirus and subsequent autoimmune myocardium impairments Antibodies to the beta1-adrenergic receptor beta1AR, which are detected in a substantial number of patients with "idiopathic" DCM,  may increase the concentration of intracellular cAMP and intracellular Ca2, a condition often leading to a transient hyper-performance of the heart followed by depressed heart function and heart failure

1 Data Sets

179 Genes

0 Proteins