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Pathway : Gastric acid secretion

Identifier  04971 Description  Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections The principal stimulants of acid secretion at the level of the parietal cell are histamine paracrine, gastrin hormonal, and acetycholine ACh; neurocrine Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H,K-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H secretion into the stomach lumen

1 Data Sets

147 Genes

0 Proteins