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Pathway : Insulin signaling pathway

Identifier  04910 Description  Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates IRS by the insulin receptor tyrosine kinase INSR This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase PI3K PI3K activates 3-phosphoinositide-dependent protein kinase 1 PDK1, which activates Akt, a serine kinase Akt in turn deactivates glycogen synthase kinase 3 GSK-3, leading to activation of glycogen synthase GYS and thus glycogen synthesis Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR

1 Data Sets

276 Genes

0 Proteins