help  | about  | cite  | software

Pathway : Glioma

Identifier  05214 Description  Gliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms Gliomas include tumours that are composed predominantly of astrocytes astrocytomas, oligodendrocytes oligodendrogliomas, mixtures of various glial cells for example,oligoastrocytomas and ependymal cells ependymomas The most malignant form of infiltrating astrocytoma - glioblastoma multiforme GBM - is one of the most aggressive human cancers GBM may develop de novo primary glioblastoma or by progression from low-grade or anaplastic astrocytoma secondary glioblastoma  Primary glioblastomas develop in older patients and typically show genetic alterations EGFR amplification, p16/INK4a deletion, and PTEN mutations at frequencies of 24-34% Secondary glioblastomas develop in younger patients and frequently show overexpression of PDGF and CDK4 as well as p53 mutations 65% and loss of Rb playing major roles in such transformations Loss of PTEN has been implicated in both pathways, although it is much more common in the pathogenesis of primary GBM

1 Data Sets

130 Genes

0 Proteins