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Pathway : Long-term depression

Identifier  04730 Description  Cerebellar long-term depression LTD, thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber PF and Purkinje cells PCs induced by the conjunctive activation of PFs and climbing fiber CF Multiple signal transduction pathways have been shown to be involved in this process Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels VGCCs and causes a generalized influx of calcium These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse This may take place either through receptor internalization and/or through receptor desensitization

1 Data Sets

142 Genes

0 Proteins