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Pathway : Autoimmune thyroid disease

Identifier  05320 Description  The classification of autoimmune throid disease AITD includes Hashimoto's thyroiditis HT or chronic autoimmune thyroiditis and its variants,  Graves' disease GD and autoimmune atrophic thyroiditis or primary myxedema HT is characterized by the presence of goitre, thyroid autoantibodies against thyroid peroxidase TPO and thyroglobulin Tg in serum and varying degrees of thyroid dysfunction During HT, self-reactive CD4 T lymphocytes Th recruit B cells and CD8 T cells CTL into the thyroid Disease progression leads to the death of thyroid cells and hypothyroidism Both autoantibodies and thyroid-specific cytotoxic T lymphocytes CTLs have been proposed to be responsible for autoimmune thyrocyte depletion In GD, the TSH-R is the most important autoantigen Antibodies directed against it mimic the effects of the hormone on thyroid cells, TSH, stimulating autonomous production of thyroxine and triiodothyronine and causing hyperthyroidism The presence of  TSH-R-blocking antibodies that bind the TSH receptor in a similar fashion to the antibodies in patients with Grave's disease but that block rather than activate the receptor explains some cases of atrophic hypothyroidism

1 Data Sets

118 Genes

0 Proteins