help  | about  | cite  | software

Pathway : Systemic lupus erythematosus

Identifier  05322 Description  Systemic lupus erythematosus SLE is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components, in association with a diverse array of clinical manifestations The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc{gamma}R-mediated neutrophil and macrophage activation Activation of complement C5 leads to injury both through formation of the membrane attack complex C5b-9 or by generation of the anaphylatoxin and cell activator C5a Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases

1 Data Sets

284 Genes

0 Proteins