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Pathway : Two-component system

Identifier  02020 Description  Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state Each two-component system consists of a sensor protein-histidine kinase HK and a response regulator RR In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signals in the environment Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR The activated RR can then effect changes in cellular physiology, often by regulating gene expression Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription

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