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Pathway : MAPK signaling pathway - yeast

Identifier  04011 Description  The S cerevisiae genome encodes multiple MAP kinase orthologs One Fus3 mediates cellular response to peptide pheromones Another Kss1 permits adjustment to nutrient limiting conditions A third Hog1 is necessary for survival under hyperosmotic conditions A fourth Slt2/Mpk1 is required for repair of injuries to the cell wall As in mammalian cells, these pathways consist of a conserved module in which three kinases phosphorylate each other in sequence The MAPK is phosphorylated by the MAPK/ERK kinase MEK, which is itself phosphorylated by a MEK kinase MEKK

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